2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N9504
    Polyschistine A 96562-88-8 98%
    Polyschistine A is a norditerpene alkaloid with potential analgesic properties.
    Polyschistine A
  • HY-N9513
    Echimidine N-oxide 41093-89-4 98%
    Echimidine N-oxide, a pyrrolizidine alkaloid, has acetylcholinesterase (AChE) inhibitory activity (IC50=0.347 mM).
    Echimidine N-oxide
  • HY-N9587
    Tricin 7-O-β-D-glucopyranoside 32769-01-0 98%
    Tricin 7-O-β-D-glucopyranoside is a potent and orally active neuroprotective agent. Tricin 7-O-β-D-glucopyranoside induces Apoptosis.html" class="link-product" target="_blank">Apoptosis. Tricin 7-O-β-D-glucopyranoside decreases the expression of TNF-α induced phosphor-κB-α, phosphor-NF-κB, HMGB1.
    Tricin 7-O-β-D-glucopyranoside
  • HY-N9615
    Azadiradione 26241-51-0 98%
    Azadiradione is a bioactive limonoid found in Azadirachta indica. Azadiradione is a HSF1 activator. Azadiradione has antimycobacterial, anti-nociceptive and anti-inflammatory activities.
    Azadiradione
  • HY-N9736
    6,4'-Dihydroxy-7-methoxyflavanone 189689-32-5 98%
    6,4'-Dihydroxy-7-methoxyflavanone, a flavonoid, is a nature product that could be isolated from Heartwood Dalbergia odorifera. 6,4'-Dihydroxy-7-methoxyflavanone inhibits receptor activators of nuclear factor kappa-B ligand (RANKL) induced osteoclastogenesis. 6,4'-Dihydroxy-7-methoxyflavanone has antioxidant, anti-inflammatory and neuroprotective effects. 6,4'-Dihydroxy-7-methoxyflavanone can be used in research of osteoporosis.
    6,4'-Dihydroxy-7-methoxyflavanone
  • HY-N9737
    (−)-Acutumine 17088-50-5 98%
    (−)-Acutumine is a tetracyclic chloroalkaloid that exhibits selective cytotoxicity to cultured human T cells and memory-enhancing properties in the Wistar rat model.
    (−)-Acutumine
  • HY-N9949
    Sparteine 24915-04-6 98%
    Sparteine (Lupinidine) is an alkaloid compound derived from leguminous plants and can act as a ganglionic blocker. Sparteine competitively inhibits the activity of the neuronal nicotinic acetylcholine receptor (nACh receptor).
    Sparteine
  • HY-NP142
    Methamphetamine-BSA 98%
    Methamphetamine-BSA is a protein consists of Methamphetamine and Bovine Serum Albumin (BSA). Methamphetamine-BSA is an antigen to generate specific antibodies for the detection of Methamphetamine in biological samples.
    Methamphetamine-BSA
  • HY-NP143
    Nerve Growth Factor 2.5S,murine submaxillary gland 93928-24-6 98%
    Nerve Growth Factor 2.5S, murine submaxillary gland is a neurotrophic polypeptide required for normal growth and development of sympathetic and embryonic sensory neurons and certain cholinergic neurons in the central nervous system. Nerve Growth Factor 2.5S, murine submaxillary gland has only β-subunit , and shows nerve growth-promoting activity.
    Nerve Growth Factor 2.5S,murine submaxillary gland
  • HY-NP144
    Nerve Growth Factor 7S,murine submaxillary gland 93928-24-6 98%
    Nerve Growth Factor 7S, murine submaxillary gland is an α2β2γ2 complex in which the β-NGF dimer (the active neurotrophin) is associated with two α-NGF and two γ-NGF subunits.
    Nerve Growth Factor 7S,murine submaxillary gland
  • HY-P0041
    F992 162277-99-8 98%
    F992 is an antidiuretic peptide and vasopressin (antidiuretic hormone) analogue.
    F992
  • HY-P0066
    Contulakin G 229180-41-0 98%
    Contulakin G is an O-glycosylated invertebrate neurotensin. Contulakin-G is a weaker agonist for the neurotensin receptor. Contulakin G is also a potent antinociceptive agent.
    Contulakin G
  • HY-P0133
    (Arg) 9 143413-47-2 98%
    (Arg)9 (Nona-L-arginine) is a cell-penetrating peptide (CPP) made up of 9 arginine residues, which is an inhibitor of serine endoprotease Furin. (Arg)9 has neuroprotective property, exhibits neuroprotective activity with an IC50 of 0.78 μM in the glutamic acid model.
    (Arg) 9
  • HY-P0184
    Camstatin 1002295-95-5 98%
    Camstatin, a functionally active 25-residue fragment of PEP-19's IQ motif, binds calmodulin and inhibits neuronal nitric oxide (NO) synthase.
    Camstatin
  • HY-P0194
    NocII 188119-47-3 98%
    NocII is an orphan neuropeptide which stimulates locomotion in mice.
    NocII
  • HY-P0214
    Autocamtide-2-related inhibitory peptide 167114-91-2 98%
    Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM.
    Autocamtide-2-related inhibitory peptide
  • HY-P0228
    PKA RII peptide 113873-67-9 98%
    PKA RII peptide is a PKA substrate that, after being phosphorylated at the serine residue, can be used for the detection of calcineurin activity.
    PKA RII peptide
  • HY-P1017
    MDL 29913 135721-56-1 98%
    MDL 29913, a cyclic pseudopeptide, is a competitive NK2 tachykinin receptor selective antagonist, with a pA2 of 8.66.
    MDL 29913
  • HY-P1020
    Nocistatin(human) 212609-11-5 98%
    Nocistatin (human) blocks nociceptin-induced allodynia and hyperalgesia, and attenuates pain evoked by prostaglandin E2.
    Nocistatin(human)
  • HY-P1051
    β-Amyloid (12-28) 107015-83-8 98%
    β-Amyloid (12-28) (Amyloid β-Protein (12-28)) is a peptide fragment of β-amyloid protein (β1-42). β1-42, a 42 amino acid protein , is the major component of senile plaque cores. β-Amyloid (12-28) shows aggregation properties. β-Amyloid (12-28) has the potential for Alzheimer’s disease research.
    β-Amyloid (12-28)
Cat. No. Product Name / Synonyms Application Reactivity